United States securities and exchange commission logo

                             May 21, 2021

       Andrew Hirsch
       Chief Executive Officer
       C4 Therapeutics, Inc.
       490 Arsenal Way, Suite 200
       Watertown, MA 02472

                                                        Re: C4 Therapeutics,
                                                            Draft Registration
Statement on Form S-1
                                                            Submitted May 19,
                                                            CIK No. 0001662579

       Dear Mr. Hirsch:

                                                        This is to advise you
that we do not intend to review your registration statement.

               We request that you publicly file your registration statement no
later than 48 hours prior
       to the requested effective date and time. Please refer to Rules 460 and
461 regarding requests for
       acceleration. We remind you that the company and its management are
responsible for the
       accuracy and adequacy of their disclosures, notwithstanding any review,
comments, action or
       absence of action by the staff.

                                                        Please contact Jane
Park at 202-551-7439 with any questions.


                             Division of Corporation Finance

                             Office of Life Sciences
       cc:                                              Edwin O   Connor, Esq.