United States securities and exchange commission logo May 21, 2021 Andrew Hirsch Chief Executive Officer C4 Therapeutics, Inc. 490 Arsenal Way, Suite 200 Watertown, MA 02472 Re: C4 Therapeutics, Inc. Draft Registration Statement on Form S-1 Submitted May 19, 2021 CIK No. 0001662579 Dear Mr. Hirsch: This is to advise you that we do not intend to review your registration statement. We request that you publicly file your registration statement no later than 48 hours prior to the requested effective date and time. Please refer to Rules 460 and 461 regarding requests for acceleration. We remind you that the company and its management are responsible for the accuracy and adequacy of their disclosures, notwithstanding any review, comments, action or absence of action by the staff. Please contact Jane Park at 202-551-7439 with any questions. Sincerely, Division of Corporation Finance Office of Life Sciences cc: Edwin O Connor, Esq.