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  <xs:element id="cccc_StockIssuedDuringPeriodSharesWarrantsExercised" abstract="false" name="StockIssuedDuringPeriodSharesWarrantsExercised" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="cccc_StockIssuedDuringPeriodValueWarrantsExercised" abstract="false" name="StockIssuedDuringPeriodValueWarrantsExercised" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="cccc_AdjustmentsToAdditionalPaidInCapitalOtherShares" abstract="false" name="AdjustmentsToAdditionalPaidInCapitalOtherShares" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="cccc_WarrantsAndRightsOutstandingTextBlock" abstract="false" name="WarrantsAndRightsOutstandingTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="cccc_UnauditedInterimFinancialInformationPolicyPolicyTextBlock" abstract="false" name="UnauditedInterimFinancialInformationPolicyPolicyTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="cccc_SummaryOfAllocationOfTotalTransactionPriceAndUnsatisfiedTransactionPriceTableTableTextBlock" abstract="false" name="SummaryOfAllocationOfTotalTransactionPriceAndUnsatisfiedTransactionPriceTableTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="cccc_RevenueFromCollaborationAgreementsTableTableTextBlock" abstract="false" name="RevenueFromCollaborationAgreementsTableTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="cccc_FinancialInformationRelatedToCollaborationAndLicenseAgreementsTableTableTextBlock" abstract="false" name="FinancialInformationRelatedToCollaborationAndLicenseAgreementsTableTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="cccc_SupplementalFinancialInformationRelatedToCollaborationAndLicenseAgreementsTableTableTextBlock" abstract="false" name="SupplementalFinancialInformationRelatedToCollaborationAndLicenseAgreementsTableTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="cccc_DebtSecuritiesAvailableForSaleCurrentAbstract" abstract="true" name="DebtSecuritiesAvailableForSaleCurrentAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="cccc_DebtSecuritiesAvailableForSaleAccumulatedGrossUnrealizedGainBeforeTaxCurrent" abstract="false" name="DebtSecuritiesAvailableForSaleAccumulatedGrossUnrealizedGainBeforeTaxCurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="cccc_DebtSecuritiesAvailableForSaleAccumulatedGrossUnrealizedLossBeforeTaxCurrent" abstract="false" name="DebtSecuritiesAvailableForSaleAccumulatedGrossUnrealizedLossBeforeTaxCurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="cccc_DebtSecuritiesAvailableForSaleNoncurrentAbstract" abstract="true" name="DebtSecuritiesAvailableForSaleNoncurrentAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="cccc_DebtSecuritiesAvailableForSaleAccumulatedGrossUnrealizedGainBeforeTaxNoncurrent" abstract="false" name="DebtSecuritiesAvailableForSaleAccumulatedGrossUnrealizedGainBeforeTaxNoncurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="cccc_DebtSecuritiesAvailableForSaleAccumulatedGrossUnrealizedLossBeforeTaxNoncurrent" abstract="false" name="DebtSecuritiesAvailableForSaleAccumulatedGrossUnrealizedLossBeforeTaxNoncurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="cccc_LaboratoryEquipmentMember" abstract="true" name="LaboratoryEquipmentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="cccc_AccruedResearchAndDevelopmentCurrent" abstract="false" name="AccruedResearchAndDevelopmentCurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="cccc_MKDGAgreementMember" abstract="true" name="MKDGAgreementMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="cccc_BettaAgreementMember" abstract="true" name="BettaAgreementMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="cccc_RestatedRocheAgreementMember" abstract="true" name="RestatedRocheAgreementMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="cccc_BiogenResearchAndLicenseAgreementMember" abstract="true" name="BiogenResearchAndLicenseAgreementMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="cccc_MerckAgreementMember" abstract="true" name="MerckAgreementMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="cccc_RestatedRocheAgreementAndBiogenLicenseAgreementMember" abstract="true" name="RestatedRocheAgreementAndBiogenLicenseAgreementMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="cccc_MerckKGaAAgreementMember" abstract="true" name="MerckKGaAAgreementMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="cccc_LeadSeriesIdentificationAchievementMember" abstract="true" name="LeadSeriesIdentificationAchievementMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="cccc_DiscoveryRegulatoryAndCommercialMilestonesMember" abstract="true" name="DiscoveryRegulatoryAndCommercialMilestonesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="cccc_ResearchAndDevelopmentMilestonesMember" abstract="true" name="ResearchAndDevelopmentMilestonesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="cccc_ResearchDevelopmentAndCommercialMilestonePaymentsMember" abstract="true" name="ResearchDevelopmentAndCommercialMilestonePaymentsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="cccc_OneTimeSalesBasedPaymentsMember" abstract="true" name="OneTimeSalesBasedPaymentsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="cccc_DrugApplicationApprovalMember" abstract="true" name="DrugApplicationApprovalMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="cccc_NumberOfPotentialResearchAndDevelopmentTargets" abstract="false" name="NumberOfPotentialResearchAndDevelopmentTargets" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="cccc_UpfrontPayment" abstract="false" name="UpfrontPayment" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="cccc_CollaborativeArrangementRegulatoryMilestoneAchieved" abstract="false" name="CollaborativeArrangementRegulatoryMilestoneAchieved" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="cccc_CollaborativeArrangementAdditionToTheTransactionPrice" abstract="false" name="CollaborativeArrangementAdditionToTheTransactionPrice" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="cccc_NumberOfRemainingResearchAndDevelopmentTargets" abstract="false" name="NumberOfRemainingResearchAndDevelopmentTargets" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="cccc_NoticePeriodForTerminationOfAgreement" abstract="false" name="NoticePeriodForTerminationOfAgreement" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="cccc_NumberOfPerformanceObligations" abstract="false" name="NumberOfPerformanceObligations" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="cccc_TransactionPriceAllocatedToPerformanceObligation" abstract="false" name="TransactionPriceAllocatedToPerformanceObligation" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="cccc_StockRepurchaseProgramPremiumPercentage" abstract="false" name="StockRepurchaseProgramPremiumPercentage" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="cccc_StockRepurchaseProgramDurationOfTradingDayVolumeWeightedAverageClosingPrice" abstract="false" name="StockRepurchaseProgramDurationOfTradingDayVolumeWeightedAverageClosingPrice" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="cccc_StockRepurchaseProgramTradingDaysPriorToTheEffectiveDateOfTheStockPurchaseAgreement" abstract="false" name="StockRepurchaseProgramTradingDaysPriorToTheEffectiveDateOfTheStockPurchaseAgreement" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="cccc_PremiumFromIssuanceOfCommonStock" abstract="false" name="PremiumFromIssuanceOfCommonStock" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="cccc_CollaborativeArrangementEstimatedTransactionPrice" abstract="false" name="CollaborativeArrangementEstimatedTransactionPrice" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="cccc_TransactionPriceFromClosingOfTheStockPurchaseAgreement" abstract="false" name="TransactionPriceFromClosingOfTheStockPurchaseAgreement" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="cccc_ExpectedConsiderationToBeReceivedFromManufacturedClinicalSupply" abstract="false" name="ExpectedConsiderationToBeReceivedFromManufacturedClinicalSupply" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="cccc_AdditionalUpfrontConsideration" abstract="false" name="AdditionalUpfrontConsideration" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="cccc_NumberOfPotentialTargets" abstract="false" name="NumberOfPotentialTargets" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="cccc_NumberOfTargets" abstract="false" name="NumberOfTargets" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="cccc_AnnualResearchPlanPaymentsReceivables" abstract="false" name="AnnualResearchPlanPaymentsReceivables" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="cccc_UpfrontFees" abstract="false" name="UpfrontFees" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="cccc_OptionExerciseFee" abstract="false" name="OptionExerciseFee" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="cccc_NumberOfTargetedProteinDegradation" abstract="false" name="NumberOfTargetedProteinDegradation" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="cccc_ResearchAndDevelopmentAgreementPeriod" abstract="false" name="ResearchAndDevelopmentAgreementPeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="cccc_NonRefundableUpfrontPayment" abstract="false" name="NonRefundableUpfrontPayment" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="cccc_ResearchAndDevelopmentTargetsMember" abstract="true" name="ResearchAndDevelopmentTargetsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="cccc_OptionRightsMember" abstract="true" name="OptionRightsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="cccc_TransactionPriceUnsatisfiedToPerformanceObligation" abstract="false" name="TransactionPriceUnsatisfiedToPerformanceObligation" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="cccc_RocheAgreementMember" abstract="true" name="RocheAgreementMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="cccc_BiogenAgreementMember" abstract="true" name="BiogenAgreementMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="cccc_AtTheMarketMember" abstract="true" name="AtTheMarketMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="cccc_UnderwrittenOfferingMember" abstract="true" name="UnderwrittenOfferingMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="cccc_PreFundedWarrantsMember" abstract="true" name="PreFundedWarrantsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="cccc_ClassAWarrantsMember" abstract="true" name="ClassAWarrantsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="cccc_ClassBWarrantsMember" abstract="true" name="ClassBWarrantsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="cccc_ClassAAndClassBWarrantsMember" abstract="true" name="ClassAAndClassBWarrantsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="cccc_PreFundedWarrantsAndClassAAndClassBWarrantsMember" abstract="true" name="PreFundedWarrantsAndClassAAndClassBWarrantsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="cccc_SaleOfStockValueAuthorizedForSale" abstract="false" name="SaleOfStockValueAuthorizedForSale" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="cccc_SaleOfStockTotalConsiderationReceivedOnTransactionPotentialExpected" abstract="false" name="SaleOfStockTotalConsiderationReceivedOnTransactionPotentialExpected" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="cccc_ExercisedWarrantOrRightClassAxis" abstract="true" name="ExercisedWarrantOrRightClassAxis" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:dimensionItem" type="xbrli:stringItemType"/>
  <xs:element id="cccc_ExercisedWarrantOrRightClassDomain" abstract="true" name="ExercisedWarrantOrRightClassDomain" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="cccc_ClassOfWarrantOrRightIssuedShares" abstract="false" name="ClassOfWarrantOrRightIssuedShares" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="cccc_ClassOfWarrantOrRightNumberOfConsecutiveTradingDaysPriorToTheDateOfNoticeOfMandatoryExercise" abstract="false" name="ClassOfWarrantOrRightNumberOfConsecutiveTradingDaysPriorToTheDateOfNoticeOfMandatoryExercise" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="cccc_ClassOfWarrantOrRightPotentialMandatoryExerciseMinimumPeriodAfterIssuance" abstract="false" name="ClassOfWarrantOrRightPotentialMandatoryExerciseMinimumPeriodAfterIssuance" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="cccc_SharePriceMinimumThresholdForConsecutiveTradingDays" abstract="false" name="SharePriceMinimumThresholdForConsecutiveTradingDays" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types:perShareItemType"/>
  <xs:element id="cccc_ClassOfWarrantOrRightRollForward" abstract="true" name="ClassOfWarrantOrRightRollForward" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="cccc_PerformanceAcceleratedRestrictedStockUnitsMember" abstract="true" name="PerformanceAcceleratedRestrictedStockUnitsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="cccc_TwoThousandAndTwentyStockOptionAndIncentivePlanMember" abstract="true" name="TwoThousandAndTwentyStockOptionAndIncentivePlanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="cccc_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfCommonStockIssuablePerRSUVested" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfCommonStockIssuablePerRSUVested" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="cccc_OptionsToPurchaseCommonStockMember" abstract="true" name="OptionsToPurchaseCommonStockMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="cccc_ReportableSegmentMember" abstract="true" name="ReportableSegmentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="cccc_DevelopmentExpenses" abstract="false" name="DevelopmentExpenses" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="cccc_ResearchExpenses" abstract="false" name="ResearchExpenses" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="cccc_A2026RocheAgreementMember" abstract="true" name="A2026RocheAgreementMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="cccc_UpfrontConsiderationReceivable" abstract="false" name="UpfrontConsiderationReceivable" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
</xs:schema>
