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Segments [Axis] Segments [Axis] Change in Fair Value as of Vesting Date of Prior Year Equity Awards Vested in Covered Year Change in Fair Value as of Vesting Date of Prior Year Equity Awards Vested in Covered Year [Member] Income tax benefit computed at federal statutory tax rate Effective Income Tax Rate Reconciliation, at Federal Statutory Income Tax Rate, Percent Property, Plant and Equipment [Abstract] Property, Plant and Equipment [Abstract] Exercise Price Award Exercise Price Debt Securities, Available-for-Sale, Unrealized Loss Position [Abstract] Debt Securities, Available-for-Sale, Unrealized Loss Position [Abstract] Lease Contractual Term Lease Contractual Term [Axis] Schedule of deferred tax assets and liabilities Schedule of Deferred Tax Assets and Liabilities [Table Text Block] Net loss per share Earnings Per Share [Text Block] Arrangement Duration Trading Arrangement Duration Issuance of common stock under the 2020 ESPP Stock Issued During Period, Value, Employee Stock Purchase Plan Subsequent event Subsequent Event [Member] Number of potential targets Number Of Potential Targets Number of potential targets. Exercise of stock options and release of stock units Stock Issued During Period, Value, Stock Options Exercised Stockholders’ equity: Equity, Attributable to Parent [Abstract] Granted (in dollars per share) Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Grants in Period, Weighted Average Grant Date Fair Value Marketable securities in continuous unrealized loss position for less than 12 months Debt Securities, Available-for-Sale, Continuous Unrealized Loss Position, Less than 12 Months Written notice period for termination of agreement Notice Period For Termination Of Agreement Notice period for termination of agreement. Federal Domestic Tax Jurisdiction [Member] Income taxes Income Tax, Policy [Policy Text Block] Peer Group Issuers, Footnote Peer Group Issuers, Footnote [Text Block] MKDG Agreement MKDG Agreement [Member] MKDG Agreement Payment of long-term debt − related party Repayments of Related Party Debt Segments [Domain] Segments [Domain] Interest and other income, net Interest and Other Income Material Terms of Trading Arrangement Material Terms of Trading Arrangement [Text Block] Net operating loss carryforwards limited and expire due to ownership changes Net Operating Loss Carryforwards, Limited And Expired Due To Ownership Changes Net operating loss carryforwards limited and expire due to ownership changes. All Individuals All Individuals [Member] Amount payable for extend research term option Amount Payable For Extend Research Term Option Amount payable for extend research term option. PEO PEO [Member] Income Tax Disclosure [Abstract] Income Tax Disclosure [Abstract] Name Trading Arrangement, Individual Name Expected dividend yield Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Dividend Payments Statement of Stockholders' Equity [Abstract] Statement of Stockholders' Equity [Abstract] Additional upfront consideration received Additional Upfront Consideration Additional upfront consideration. Long-Lived Tangible Asset Long-Lived Tangible Asset [Axis] Entity Public Float Entity Public Float Gross Unrealized Gains Debt Securities, Available-for-Sale, Accumulated Gross Unrealized Gain, before Tax Trading days prior to the effective date of the stock purchase agreement Sale of Stock, Trading Days Prior To The Effective Date Of The Stock Purchase Agreement Sale of Stock, Trading Days Prior To The Effective Date Of The Stock Purchase Agreement Awards Close in Time to MNPI Disclosures, Table Awards Close in Time to MNPI Disclosures [Table Text Block] Share-Based Payment Arrangement, Tranche Three Share-Based Payment Arrangement, Tranche Three [Member] Schedule Of Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Table] Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table] Common stock shares reserved for issuance Common Stock, Capital Shares Reserved for Future Issuance Prior Year End Fair Value of Equity Awards Granted in Any Prior Year that Fail to Meet Applicable Vesting Conditions During Covered Year Prior Year End Fair Value of Equity Awards Granted in Any Prior Year that Fail to Meet Applicable Vesting Conditions During Covered Year [Member] Beginning balance (in shares) Ending balance (in shares) Shares, Outstanding Federal net operating loss carryforwards do not expire Deferred Tax Assets, Operating Loss Carryforwards, Not Subject to Expiration Cash equivalents Cash and Cash Equivalents, Fair Value Disclosure Aggregate Erroneous Compensation Amount Aggregate Erroneous Compensation Amount Estimated transaction price Collaborative Arrangement, Estimated Transaction Price Collaborative Arrangement, Estimated Transaction Price Research agreement, period Research And Development, Agreement Period Research and development agreement period. Local Phone Number Local Phone Number Deferred tax assets, valuation allowance Less: valuation allowance Deferred Tax Assets, Valuation Allowance Aggregate Erroneous Compensation Not Yet Determined Aggregate Erroneous Compensation Not Yet Determined [Text Block] Total operating expenses Operating Expenses Risk-free interest rate, maximum Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Risk Free Interest Rate, Maximum Transaction Price Unsatisfied Transaction Price Unsatisfied To Performance Obligation Transaction price unsatisfied to performance obligation. Total marketable securities in unrealized loss position, Number of securities Debt Securities, Available-for-Sale, Unrealized Loss Position, Number of Positions Options, Additional Disclosures Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Additional Disclosures [Abstract] Changes in operating assets and liabilities: Increase (Decrease) in Operating Capital [Abstract] Laboratory equipment Laboratory equipment Laboratory Equipment [Member] Laboratory equipment. PEO Total Compensation Amount PEO Total Compensation Amount Credit Agreement with Perceptive Life Sciences Master Fund LTD Credit Agreement With Perceptive Life Sciences Master Fund L T D [Member] Credit agreement with Perceptive Life Sciences Master Fund LTD. Deferred federal provision Deferred Federal Income Tax Expense (Benefit) Marketable securities Fair Value Debt Securities, Available-for-Sale, Excluding Accrued Interest Long-Lived Tangible Asset Long-Lived Tangible Asset [Domain] Summary of accrued expenses and other current liabilities Schedule of Accrued Liabilities [Table Text Block] Marketable securities, non-current Fair Value Debt Securities, Available-for-Sale, Excluding Accrued Interest, Noncurrent Statement of Income Location, Balance Statement of Income Location, Balance [Axis] Options vested and expected to vest (in dollars per share) Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Outstanding, Weighted Average Exercise Price Cash equivalents Cash and Cash Equivalents, Policy [Policy Text Block] Commitments and contingencies Commitments and Contingencies Disclosure [Text Block] Debt Disclosure [Abstract] Other Adjustments to Additional Paid in Capital, Other Common Stock Common Stock [Member] Measure: Measure [Axis] Issuance of common stock upon vesting of restricted stock units, net of shares repurchased for tax withholding Shares Issued, Value, Share-Based Payment Arrangement, after Forfeiture Preferred stock, shares authorized Preferred Stock, Shares Authorized Forgone Recovery due to Expense of Enforcement, Amount Forgone Recovery due to Expense of Enforcement, Amount Issuance of common stock, net (in shares) Stock Issued During Period, Shares, New Issues Marketable securities in continuous unrealized loss position for greater than 12 months, Number of securities Debt Securities, Available-for-Sale, Continuous Unrealized Loss Position, 12 Months or Longer, Number of Positions Entity Emerging Growth Company Entity Emerging Growth Company Term Loan Term Loan [Member] Term loan. Segment Reporting [Abstract] Number of shares retained to cover statutory minimum withholding taxes Share-Based Payment Arrangement, Shares Withheld for Tax Withholding Obligation Entity Central Index Key Entity Central Index Key Adjustments or reconciling items Segment Reporting, Other Segment Item, Amount General and administrative General and Administrative Expense [Member] Lessee Lease Description [Table] Lessee, Lease, Description [Table] Accrued expenses and other current liabilities Accounts Payable, Accrued Liabilities, and Other Liabilities Disclosure, Current [Text Block] Accrued interest or penalties related to uncertain tax benefits Unrecognized Tax Benefits, Income Tax Penalties and Interest Accrued Non-GAAP Measure Description Non-GAAP Measure Description [Text Block] Non-PEO NEO Average Compensation Actually Paid Amount Non-PEO NEO Average Compensation Actually Paid Amount Expected volatility, minimum Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Volatility Rate, Minimum Research extend term Research Extended Term Research extended term. Stockholder's equity Equity [Text Block] Restated Roche Agreement Restated Roche Agreement [Member] Restated Roche agreement. Award Timing, How MNPI Considered Award Timing, How MNPI Considered [Text Block] Equity Component Equity Component [Domain] Preferred stock, par value (in dollars per share) Preferred Stock, Par or Stated Value Per Share Financial Instrument [Axis] Financial Instrument [Axis] Segment Reporting Segment Reporting Disclosure [Text Block] Reconciliation of cash, cash equivalents and restricted cash: Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents [Abstract] Schedule of revenue from collaboration agreements Revenue From Collaboration Agreements Table [Table Text Block] Revenue from collaboration agreements. Additional 402(v) Disclosure Additional 402(v) Disclosure [Text Block] Stock-based compensation APIC, Share-Based Payment Arrangement, Increase for Cost Recognition Transaction price allocated to performance obligation Transaction Price Allocated Transaction Price Allocated To Performance Obligation Transaction price allocated to performance obligation. Entity Shell Company Entity Shell Company Calico Agreement Calico Agreement [Member] Calico agreement. Entity Incorporation, State or Country Code Entity Incorporation, State or Country Code Comprehensive loss Comprehensive Income, Policy [Policy Text Block] Upfront payment Upfront Payment Upfront payment. Title Trading Arrangement, Individual Title Statement [Table] Statement [Table] Defined Contribution Plan [Table] Defined Contribution Plan [Table] Tranche one Tranche One [Member] Tranche one. Summary of significant accounting policies Significant Accounting Policies [Text Block] Debt Securities, Available-for-Sale, Continuous Unrealized Loss Position, Number of Positions [Abstract] Debt Securities, Available-for-Sale, Continuous Unrealized Loss Position, Number of Positions [Abstract] Consolidation Items [Domain] Consolidation Items [Domain] IRS Internal Revenue Service (IRS) [Member] City Area Code City Area Code Current liabilities: Liabilities, Current [Abstract] Auditor location Auditor Location Cash paid for interest - related party Interest Paid, Excluding Capitalized Interest, Operating Activities Insider Trading Policies and Procedures Not Adopted Insider Trading Policies and Procedures Not Adopted [Text Block] Level 1 Fair Value, Inputs, Level 1 [Member] Total current assets Assets, Current Statement of Cash Flows [Abstract] Statement of Cash Flows [Abstract] Supplemental disclosures of non-cash investing and financing activities: Noncash Investing and Financing Items [Abstract] Payments for repurchase of common stock for tax withholding Payments for Repurchase of Common Stock Options exercisable (in shares) Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Number Calico License Agreement Calico License Agreement [Member] Calico license agreement. Schedule of Segment Reporting Information, by Segment [Table] Schedule of Segment Reporting Information, by Segment [Table] Weighted-Average Grant Date Fair Value Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value [Abstract] Weighted-average fair value of options granted (in dollars per share) Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value Entity Well-known Seasoned Issuer Entity Well-known Seasoned Issuer Subsequent Event Type Subsequent Event Type [Axis] Income taxes Income Tax Disclosure [Text Block] 2028 Lessee, Operating Lease, Liability, to be Paid, Year Four Earnings Per Share [Abstract] Earnings Per Share [Abstract] Equity [Abstract] Equity [Abstract] Accumulated deficit Accumulated deficit Retained Earnings (Accumulated Deficit) Research and Development Arrangement, Contract to Perform for Others, Type Research and Development Arrangement, Contract to Perform for Others, Type [Axis] General and administrative General and Administrative Expense Organization, Consolidation and Presentation of Financial Statements [Abstract] Organization, Consolidation and Presentation of Financial Statements [Abstract] Aggregate Available Trading Arrangement, Securities Aggregate Available Amount Equity Awards Adjustments Equity Awards Adjustments [Member] Incremental borrowing rate Operating Lease, Weighted Average Discount Rate, Percent Liabilities under lease Total operating lease liability as of December 31, 2024 Operating Lease, Liability Net cash provided by financing activities Net Cash Provided by (Used in) Financing Activities Underlying Securities Award Underlying Securities Amount Marketable securities Investments in Debt and Marketable Equity Securities (and Certain Trading Assets) Disclosure [Text Block] Number of annual offering periods (or more) Share-Based Compensation Arrangement by Share-Based Payment Award, Number Of Annual Offering Periods Share-Based Compensation Arrangement by Share-Based Payment Award, Number Of Annual Offering Periods Share-based compensation, number of common stock issuable per RSU vested Share Based Compensation Arrangement By Share Based Payment Award, Number Of Common Shares Issuable Per Vested Share-based compensation arrangement by share-based payment award, number of common stock issuable per RSU vested. Credit Facility Credit Facility [Axis] Development expenses Development Expenses Development Expenses Amendment Flag Amendment Flag Entity Registrant Name Entity Registrant Name Income Tax [Line Items] Income Tax [Line Items] Income tax. Unrealized gain on marketable securities Marketable Security, Unrealized Gain (Loss) Adjustment to Non-PEO NEO Compensation Footnote Adjustment to Non-PEO NEO Compensation Footnote [Text Block] Stock Appreciation Rights (SARs) Stock Appreciation Rights (SARs) [Member] Marketable securities in continuous unrealized loss position for less than 12 months, Number of securities Debt Securities, Available-for-Sale, Continuous Unrealized Loss Position, Less than 12 Months, Number of Positions Expected consideration to be received from manufactured clinical supply Expected Consideration To Be Received From Manufactured Clinical Supply Expected Consideration To Be Received From Manufactured Clinical Supply Audit Information [Abstract] Audit Information [Abstract] Deferred state provision Deferred State and Local Income Tax Expense (Benefit) Regulatory milestone achieved Collaborative Arrangement, Regulatory Milestone Achieved Collaborative Arrangement, Regulatory Milestone Achieved Fair Value as of Grant Date Award Grant Date Fair Value Revenue from Contract with Customer, Product and Service [Extensible Enumeration] Revenue from Contract with Customer, Product and Service [Extensible Enumeration] Aggregate intrinsic value, vested and expected to vest Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Outstanding, Aggregate Intrinsic Value Number of shares (in shares) Sale of Stock, Number of Shares Issued in Transaction Level 2 Fair Value, Inputs, Level 2 [Member] Fair Value Hierarchy and NAV Fair Value Hierarchy and NAV [Domain] Recovery of Erroneously Awarded Compensation Disclosure [Line Items] Amount eligible to receive Contracts Receivable, Claims and Uncertain Amounts Issuance of common stock, net Issuance and sale of common stock Stock Issued During Period, Value, New Issues Marketable securities, current Fair Value Debt Securities, Available-for-Sale, Excluding Accrued Interest, Current Entity Address, Postal Zip Code Entity Address, Postal Zip Code Collaborative Arrangement and Arrangement Other than Collaborative Collaborative Arrangement and Arrangement Other than Collaborative [Axis] Schedule of stock-based compensation expense Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table Text Block] Principles of consolidation Consolidation, Policy [Policy Text Block] Restatement Determination Date: Restatement Determination Date [Axis] Collaborative Arrangement and Arrangement Other than Collaborative Collaborative Arrangement and Arrangement Other than Collaborative [Domain] Title of 12(b) Security Title of 12(b) Security Premium percentage Sale of Stock, Premium Percentage Sale of Stock, Premium Percentage Common stock, par value of $0.0001 per share; 150,000,000 shares authorized, and 70,625,899 and 60,467,188 shares issued and outstanding as of December 31, 2024 and 2023, respectively Common Stock, Value, Issued Document Financial Statement Error Correction [Flag] Document Financial Statement Error Correction [Flag] Share-based Payment Arrangement [Abstract] Share-Based Payment Arrangement [Abstract] Income Tax Authority, Name Income Tax Authority, Name [Domain] U.S. government debt securities US Government Debt Securities [Member] Cash and cash equivalents Cash and cash equivalents at end of the year Cash and Cash Equivalents, at Carrying Value State tax—net of federal Effective Income Tax Rate Reconciliation, State and Local Income Taxes, Percent Year-over-Year Change in Fair Value of Equity Awards Granted in Prior Years That are Outstanding and Unvested Year-over-Year Change in Fair Value of Equity Awards Granted in Prior Years That are Outstanding and Unvested [Member] Auditor name Auditor Name Other Deferred Tax Assets, Other Gross Unrealized Gains Debt Securities, Available-for-sale, Accumulated Gross Unrealized Gain, before Tax, Current Debt Securities, Available-for-sale, Accumulated Gross Unrealized Gain, before Tax, Current Forfeited (in dollars per share) Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Forfeitures, Weighted Average Grant Date Fair Value Current tax provision: Current Income Tax Expense (Benefit), Continuing Operations [Abstract] Loss on early extinguishment of debt Loss on early extinguishment of debt Gain (Loss) on Extinguishment of Debt Cash flows provided by financing activities: Net Cash Provided by (Used in) Financing Activities [Abstract] Year-end Fair Value of Equity Awards Granted in Covered Year that are Outstanding and Unvested Year-end Fair Value of Equity Awards Granted in Covered Year that are Outstanding and Unvested [Member] Preferred stock, par value of $0.0001 per share; 10,000,000 shares authorized, and no shares issued or outstanding as of December 31, 2024 and 2023, respectively Preferred Stock, Value, Issued Estimated useful life Property, Plant and Equipment, Useful Life Number of Options Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding [Roll Forward] Cash and Cash Equivalents Cash and Cash Equivalents [Domain] Summary of lease term and incremental borrowing rate Summary Of Lease Term And Incremental Borrowing Rate Applied In Arriving At Lease Liability Table [Table Text Block] Summary of lease term and incremental borrowing rate applied in arriving at lease liability. Depreciation and amortization Depreciation, Depletion and Amortization, Nonproduction Net loss per share — basic (in dollars per share) Earnings Per Share, Basic Accounts payable Increase (Decrease) in Accounts Payable Proceeds from issuance of common stock Proceeds from Issuance of Common Stock Adjustment To PEO Compensation, Footnote Adjustment To PEO Compensation, Footnote [Text Block] Award Timing MNPI Disclosure Award Timing MNPI Disclosure [Text Block] Contractual life of options from the date of grant Share-Based Compensation Arrangement by Share-Based Payment Award, Expiration Period Deferred revenue Deferred Tax Assets, Deferred Income Federal net operating loss carryforwards Deferred Tax Assets, Operating Loss Carryforwards, Domestic Capital expenditures in accounts payable and accrued expenses Capital Expenditures Incurred but Not yet Paid Aggregate Pension Adjustments Service Cost Aggregate Pension Adjustments Service Cost [Member] Property and equipment Property, Plant and Equipment, Policy [Policy Text Block] Compensation Actually Paid vs. Other Measure Compensation Actually Paid vs. Other Measure [Text Block] Summary of marketable securities in unrealized loss position Debt Securities, Available-for-Sale, Unrealized Loss Position, Fair Value [Table Text Block] Total current liabilities Liabilities, Current Vesting Date Fair Value of Equity Awards Granted and Vested in Covered Year Vesting Date Fair Value of Equity Awards Granted and Vested in Covered Year [Member] Denominator: Weighted Average Number of Shares Outstanding, Diluted [Abstract] Total assets Assets Incremental cost of plan modification Share-Based Payment Arrangement, Plan Modification, Incremental Cost Concentrations of credit risk Concentration Risk, Credit Risk, Policy [Policy Text Block] Time-Based Restricted Stock Units Time-Based Restricted Stock Units [Member] Time-Based Restricted Stock Units Amount withdrawn Long-Term Line of Credit Granted (in shares) Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Grants in Period Purchases of property and equipment Payments to Acquire Property, Plant, and Equipment Newly Leased Space Newly Leased Space [Member] Newly leased space. Forgone Recovery due to Violation of Home Country Law, Amount Forgone Recovery due to Violation of Home Country Law, Amount Schedule of supplemental financial information related to collaboration and license agreements Supplemental Financial Information Related To Collaboration And License Agreements Table [Table Text Block] Supplemental financial information related to collaboration and license agreements. Commitments and contingencies (See Note 6 and Note 9) Commitments and Contingencies Risk-free interest rate, minimum Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Risk Free Interest Rate, Minimum Deferred revenue in accounts receivable Aggregate Exercise Price Of Warrant Net Exercised, Related Party Aggregate Exercise Price Of Warrant Net Exercised, Related Party Schedule of effective income tax rate reconciliation Schedule of Effective Income Tax Rate Reconciliation [Table Text Block] Office equipment, furniture and fixtures Office Equipment Furniture And Fixtures [Member] Office equipment, furniture and fixtures. Termination Date Trading Arrangement Termination Date Reportable Segment Reportable Segment [Member] Reportable Segment Expected volatility, maximum Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Volatility Rate, Maximum Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items] Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] 2026 Lessee, Operating Lease, Liability, to be Paid, Year Two Stock-based compensation Share-Based Payment Arrangement [Text Block] Roche Agreement Roche Agreement [Member] Roche agreement. Marketable Securities [Abstract] Marketable Securities [Abstract] 2015 Incentive Stock Option and Grant Plan Two Thousand Fifteen Incentive Stock Option And Grant Plan [Member] 2015 incentive stock option and grant plan. Entity Address, City or Town Entity Address, City or Town Payment received Proceeds from Collaborators Leases Lessee, Leases [Policy Text Block] Debt Instrument Debt Instrument [Axis] Summary of stock option activity Share-Based Payment Arrangement, Option, Activity [Table Text Block] Intrinsic value of options exercised (in thousands) Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercises in Period, Intrinsic Value Total stock-based compensation expense Share-Based Payment Arrangement, Expense Leasehold improvements Leaseholds and Leasehold Improvements [Member] Net loss Net loss Net loss Net Income (Loss) Attributable to Parent Trading Arrangement: Trading Arrangement [Axis] Options granted (in dollars per share) Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Grants in Period, Weighted Average Exercise Price Amortization of debt discount—related party Amortization of Debt Discount (Premium) Pay vs Performance Disclosure, Table Pay vs Performance [Table Text Block] Employer discretionary contribution amount Defined Contribution Plan, Employer Discretionary Contribution Amount Forfeited (in shares) Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Forfeited in Period Equity Awards Adjustments, Excluding Value Reported in Compensation Table Equity Awards Adjustments, Excluding Value Reported in the Compensation Table [Member] Annual research plan payments receivables Annual Research Plan Payments Receivables Annual research plan payments receivables. Maximum authorized payroll deduction percentage of eligible compensation for eligible employees Maximum Authorized Payroll Deduction, Percentage Of Eligible Compensation For Eligible Employees Maximum authorized payroll deduction percentage of eligible compensation for eligible employees. Dividends or Other Earnings Paid on Equity Awards not Otherwise Reflected in Total Compensation for Covered Year Dividends or Other Earnings Paid on Equity Awards not Otherwise Reflected in Total Compensation for Covered Year [Member] Entity File Number Entity File Number Cash and Cash Equivalents Cash and Cash Equivalents [Axis] Document Fiscal Year Focus Document Fiscal Year Focus Income Statement [Abstract] Income Statement [Abstract] Entity Address, Address Line One Entity Address, Address Line One Current federal provision Current Federal Tax Expense (Benefit) Entity Address, Address Line Two Entity Address, Address Line Two Debt Instrument, Name Debt Instrument, Name [Domain] Lease contract term Lessee, Operating Lease, Term of Contract Total cash equivalents and marketable securities Assets, Fair Value Disclosure Accrued expenses and other current liabilities Increase (Decrease) in Accrued Liabilities and Other Operating Liabilities Name Forgone Recovery, Individual Name Aggregate intrinsic value, exercisable Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Intrinsic Value Drug Application Approval Drug Application Approval [Member] Drug Application Approval Remaining lease term Operating Lease, Weighted Average Remaining Lease Term Document Period End Date Document Period End Date Sale of Stock Sale of Stock [Axis] Award Timing MNPI Considered Award Timing MNPI Considered [Flag] Total undiscounted lease payments Lessee, Operating Lease, Liability, to be Paid Deferred tax liabilities: Components of Deferred Tax Liabilities [Abstract] Outstanding, beginning balance (in shares) Outstanding, ending balance (in shares) Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Number Deferred revenue Increase (Decrease) in Deferred Revenue Option rights Option Rights [Member] Option rights. Insider Trading Arrangements [Line Items] Share Based Compensation Award, Tranche Four Share Based Compensation Award, Tranche Four [Member] Share Based Compensation Award, Tranche Four Outstanding Aggregate Erroneous Compensation Amount Outstanding Aggregate Erroneous Compensation Amount 2027 Lessee, Operating Lease, Liability, to be Paid, Year Three PEO Actually Paid Compensation Amount PEO Actually Paid Compensation Amount Summary of marketable securities Marketable Securities [Table Text Block] Revenue recognized that was included in the contract liability at the beginning of the period Contract with Customer, Liability, Revenue Recognized Adjustment to Compensation: Adjustment to Compensation [Axis] Prepaid expenses and other current assets Prepaid Expense and Other Assets, Current Subsidiary or Equity Method Investee, Sale of Stock, Type [Table] Subsidiary or Equity Method Investee, Sale of Stock, Type [Table] Restricted cash Restricted Cash and Cash Equivalents, Noncurrent Document Transition Report Document Transition Report Merck Agreement Merck Agreement [Member] Merck Agreement Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Table] Fair Value, Recurring and Nonrecurring [Table] Accumulated other comprehensive income (loss) Accumulated Other Comprehensive Income (Loss), Net of Tax Entity Current Reporting Status Entity Current Reporting Status Accumulated Deficit Retained Earnings [Member] Less: restricted cash Restricted Cash and Cash Equivalents Pension Adjustments Service Cost Pension Adjustments Service Cost [Member] Income Tax Authority, Name Income Tax Authority, Name [Axis] Right-of-use asset Deferred Tax Liabilities, Right Of Use Asset Deferred tax liabilities right-of-use asset. Weighted-average number of shares - basic (in shares) Weighted Average Number of Shares Outstanding, Basic Stock Price or TSR Estimation Method Stock Price or TSR Estimation Method [Text Block] Marketable securities in continuous unrealized loss position for greater than 12 months Debt Securities, Available-for-Sale, Continuous Unrealized Loss Position, 12 Months or Longer, Accumulated Loss Subsidiary, Sale of Stock [Line Items] Subsidiary, Sale of Stock [Line Items] Restricted stock units Restricted Stock Units (RSUs) [Member] Increase (Decrease) in Stockholders' Equity [Roll Forward] Increase (Decrease) in Stockholders' Equity [Roll Forward] Executive Category: Executive Category [Axis] Name Awards Close in Time to MNPI Disclosures, Individual Name Lead series identification achievement Lead Series Identification Achievement [Member] Lead series identification achievement. Options forfeited/expired (in shares) Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Forfeitures in Period Marketable securities in continuous unrealized loss position for less than 12 months Debt Securities, Available-for-Sale, Continuous Unrealized Loss Position, Less than 12 Months, Accumulated Loss Summary of income tax (benefit) expense Schedule of Components of Income Tax Expense (Benefit) [Table Text Block] Entity Filer Category Entity Filer Category Statement of Income Location, Balance Statement of Income Location, Balance [Domain] At-the-market offerings Atm Offerings [Member] ATM offerings. Biogen Research and License Agreement Biogen Research and License Agreement [Member] Biogen license agreement Company Selected Measure Name Company Selected Measure Name Collaborative Arrangement [Member]