Scientific Publications

Development of an AchillesTAG degradation system and its application to control CAR-T activity

October 22, 2021

Source

ScienceDirect

Structural Characterization of Degrader-Induced Ternary Complexes Using Hydrogen–Deuterium Exchange Mass Spectrometry and Computational Modeling: Implications for Structure-Based Design

September 28, 2021

Source

ACS Publications

Evaluation of the small-molecule BRD4-degrader CFT-2718 in small cell lung cancer and pancreatic cancer models

May 27, 2021

Source

Molecular Cancer Therapeutics

A Method for Determining the Kinetics of Small-Molecule-Induced Ubiquitination

March 29, 2021

Source

Sage Journals

High-Throughput Quantitative Assay Technologies for Accelerating the Discovery and Optimization of Targeted Protein Degradation Therapeutics

January 11, 2021

Source

Sage Journals

Targeted protein degradation and the enzymology of degraders

June 7, 2018

Source

ScienceDirect

Presentations

Discovery of CFT8919 as an oral, CNS-active, mutant-selective allosteric degrader of EGFR L858R for the treatment of EGFR inhibitor resistant non-small cell lung cancer

Source

4th Annual Targeted Protein Degradation Summit

Discovery of a Potent and Selective BRD9 BiDAC Degrader with Activity in a Preclinical Model of Synovial Sarcoma

Source

4th Annual Targeted Protein Degradation Summit

CFT7455: A novel, IKZF1/3 Degrader That Demonstrates Potent Tumor Regression in a Spectrum of Non-Hodgkin Lymphoma Xenograft Models

Source

16th Annual International Conference on Malignant Lymphoma

Preclinical Evaluation of CFT8919 as a Mutant Selective Degrader of EGFR with L858R Activating Mutations for the Treatment of Non-Small Cell Lung Cancer

Source

Keystone Symposium on Targeted Protein Degradation

Lessons Learned in Developing JAK2 Degraders

Source

Keystone Symposium on Targeted Protein Degradation

C4T Presentation at Undruggable Leaders Forum Europe

Source

Undruggable Leaders Forum Europe

CFT7455: A novel, IKZF1/3 degrader that demonstrates potent tumor regression in IMiD-resistant multiple myeloma (MM) xenograft models

Source

AACR Annual Meeting 2021

BRD9 Pre-clinical Overview

Source

North American Protein Degradation Congress, February 2021

Understanding the Nuances of Targeted Protein Degradation

Source

World Pharma Week, December 2020

Computational Methods for Degrader Ternary Complex Prediction using HDX Data

Source

Protein Structure Determination in Industry Meeting, November 2020

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